This seems like a pretty good solution.
Можно попробовать так.
Python:import sys import fileinput path_to_file = r'your\path\to\file' with fileinput.FileInput(path_to_file, inplace=True, backup='.bak', mode='rb') as file: seen = set() for line in file: if line not in seen: seen.add(line) sys.stdout.buffer.write(line) print('OK!')